Research associate @ Cochin Institute (INSERM U1016)

Strong background in bone diseases, virology, neurosciences, nephrology

Holder of a Ph.D in Biochemistry, Cellular and Molecular Biology, I have been focused on the preclinical development of therapeutic molecules, the elucidation of the mechanisms of action of these molecules and the discovery of the mechanisms involved in human pathologies (osteoarthritis, genetic brain and kidney diseases).

In this context, beyond technical skills, I have developed soft skills which allowed me to carry out the missions I have been entrusted :

Management skills :

Supervision of CROs
Coordination of expert networks
Team supervision
Scientific project management

Communication skills :

Reporting
Written and oral presentation of data
Redaction of scientific projects and documents

Scientific skills :

Study design
Development of procedures
Bibliographic and technological survey
Project review

The development of therapeutic molecules is still topical and remains a public health challenge in which I still want to get involved as a preclinical R&D project manager.

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Experiences

Mission :
- Elucidation of the genetics, molecular and cellular mechanisms of the neurological features in the frame of OCRL mutations (Lowe syndrome vs Dent disease-2)
Management skills :
- Technical team supervision (2 technicians, 3 students)
- Scientific project management (timelines, budget, risks)
- National and International collaboration (France, Germany)
- In charge of consumable (inventory management)
- In charge of a wild-field microscope
Communication skills :
- Project reporting to the supervisor
- Presentation and discussion of data internally and externally (6 poster presentations at both national/international meetings)
- Data presentation to financial support organizations (3 oral communications)
- Scientific documents redaction (4 published scientific articles, 9 abstracts and 6 posters)
- Writing of 3 scientific projects for funds (3 grants obtained via Orange Foundation, Jérôme Lejeune Foundation, French Lowe Syndrome Association)
Scientific skills :
- Design and development of GLP experimental procedures
- Analyses and interpretation of results
- Team working and troubleshooting abilities
- Literature survey
Training :
- Basis of Image J software
  Cochin Institute
  December 2012
Publications :
- Ptchd1 deficiency induces excitatory synaptic and cognitive dysfunctions in mouse.
  Ung DC, Iacono G, Méziane H, Blanchard E, Papon MA, Selten M, van Rhijn JR, Montjean R, Rucci J, Martin S, Fleet A, Birling MC, Marouillat S, Roepman R, Selloum M, Lux A, Thépault RA, Hamel P, Mittal K, Vincent JB, Dorseuil O, Stunnenberg HG, Billuart P, Nadif Kasri N, Hérault Y, Laumonnier F.
  Mol Psychiatry. 2018 May;23(5):1356-1367.
  https://www.ncbi.nlm.nih.gov/pubmed/28416808
- Functional Characterization and Rescue of a Deep Intronic Mutation in OCRL Gene Responsible for Lowe syndrome.
  Rendu J, Montjean R, Coutton C, Suri SM, Chicanne G, Petiot PA, Brocard J, Grunwald D, Rouxel FP, Payrastre B, Lunardi J, Dorseuil O, Marty I, Fauré
  Hum Mutat. 2017 Feb;38(2):152-159.
  https://www.ncbi.nlm.nih.gov/pubmed/27790796
- OCRL-mutated fibroblasts from patients with Dent-2 disease exhibit INPP5B-independent phenotypic variability relatively to Lowe syndrome cells.
  Montjean R, Aoidi R, Desbois P, Rucci J, Trichet M, Salomon R, Rendu J, Fauré J, Lunardi J, Gacon G, Billuart P, Dorseuil O.
  Hum Mol Genet. 2015 Feb 15;24(4):994-1006.
  http://www.ncbi.nlm.nih.gov/pubmed/25305077
- X-exome sequencing of 405 unresolved families identifies seven novel intellectual disability genes.
  Hu H, Haas SA, Chelly J, Van Esch H, Raynaud M, de Brouwer AP, Weinert S, Froyen G, Frints SG, Laumonnier F, Zemojtel T, Love MI, Richard H, Emde AK, Bienek M, Jensen C, Hambrock M, Fischer U, Langnick C, Feldkamp M, Wissink-Lindhout W, Lebrun N, Castelnau L, Rucci J, Montjean R, Dorseuil O, Billuart P, Stuhlmann T, Shaw M, Corbett MA, Gardner A, Willis-Owen S, Tan C, Friend KL, Belet S, van Roozendaal KE, Jimenez-Pocquet M, Moizard MP, Ronce N, Sun R, O'Keeffe S, Chenna R, van Bömmel A, Göke J, Hackett A, Field M, Christie L, Boyle J, Haan E, Nelson J, Turner G, Baynam G, Gillessen-Kaesbach G, Müller U, Steinberger D, Budny B, Badura-Stronka M, Latos-Bieleńska A, Ousager LB, Wieacker P, Rodríguez Criado G, Bondeson ML, Annerén G, Dufke A, Cohen M, Van Maldergem L, Vincent-Delorme C, Echenne B, Simon-Bouy B, Kleefstra T, Willemsen M, Fryns JP, Devriendt K, Ullmann R, Vingron M, Wrogemann K, Wienker TF, Tzschach A, van Bokhoven H, Gecz J, Jentsch TJ, Chen W, Ropers HH, Kalscheuer VM
  Mol Psychiatry. 2016 Jan;21(1):133-48.
  http://www.ncbi.nlm.nih.gov/pubmed/25644381
Oral communications :
- Syndrome de Lowe et maladie de Dent : étude fonctionnelle d’un gène modificateur
  Rodrick Montjean et Olivier Dorseuil
  Assemblée Générale de l’Association du Syndrome de Lowe (Paris, France. 19th march 2016).
- Syndrome de Lowe et maladie de Dent: Analyses moléculaires et cellulaires comparatives de fibroblastes de patients.
  Rodrick Montjean et Olivier Dorseuil
  Assemblée Générale de l’Association du Syndrome de Lowe (Paris, France. 3rd may 2014).
- Syndrome de Lowe : Conséquences sur les cellules du système nerveux (Analyse de la morphologie neuronale)
  Rodrick Montjean et Olivier Dorseuil
  Assemblée Générale de l’Association du Syndrome de Lowe (Paris, France. 6th april 2013)
Poster communications :
- Characterization of Neuronal Morphology Associated with Inactivation of Intellectual Disability and Autism Spectrum Disorders Genes.
  R. Montjean, F. Paul, J. Rucci, M. Ramos, J. Renaud, G.Pavlovic, MC. Birling, G. Iacono, H. Stunnenberg, M. Selloum, Y. Herault, J. Chelly, O. Dorseuil and P. Billuart.
  2nd International GENCODYS Conference Integrative Networks in Intellectual Disabilities (Chania, Crete, Greece. 27th-29th April 2015,).
  http://www.gencodys.eu/conference2015/conference2015.php
- Cellular and molecular mechanisms involved in intellectual deficiency of patients with Lowe syndrome
  Rodrick Montjean, Rifdat Aoidi, Pierrette Desbois, Justine Galissant, Julien Rucci, Michaël Trichet, Nicolas Lebrun, John Rendu, Julien Fauré, Rémi Salomon, Joël Lunardi, Jamel Chelly, Gérard Gacon, Pierre Billuart and Olivier Dorseuil.
  EMBO Conference-Autism and related disorders: From bench to bed (La Ciotat, France. 5th-8th September 2014).
  http://events.embo.org/14-brain/
- Compensatory mechanisms between OCRL1-mutated fibroblasts from Lowe syndrome and Dent disease patients.
  Rodrick Montjean, Rifdat Aoidi, Julien Rucci, Justine Galissant, Michael Trichet, Pierrette Desbois, Joel Lunardi, Rémi Salomon, Nicolas Lebrun, Jamel Chelly, Gérard Gacon, Pierre Billuart and Olivier Dorseuil. Congress of Young Researchers- René Descartes (Paris, France. October 2013)
  http://www.jcard.fr/index.php?page=congres
- Cognitive Disorder Genes And Neuronal Morphology Characterization
  J Rucci, R Montjean, M Ramos, J Renaud, F Laumonnier, H Stunnenberg, J Chelly, O Dorseuil, And P Billuart
  4th European Synapse Meeting (Bordeaux, France. 28th-30th August 2013)
  http://esm-bordeaux2013.risc.cnrs.fr/
- Circadian regulations of hippocampal genes and role of Ophn1, an intellectual disability gene
  J.Renaud, R. Montjean F.Dumont, S.Jacques, J.Chelly, P. Billuart and O.Dorseuil
  Gencodys 1st international conference, Integrative networks in intellectual disabilities (Paphos, Chypre. 15-17th april 2013).
  http://www.gencodys.eu/Conference/
- ID genes and synaptopathy
  J.Rucci, R.Montjean, M.Ramos, J.Renaud, J.Chelly, O.Dorseuil and P. Billuart
  Gencodys 1st international conference, Integrative networks in intellectual disabilities (Paphos, Chypre. 15-17th april 2013).
  http://www.gencodys.eu/Conference/

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Rodrick MONTJEAN, Ph.D

R&D and preclinical development manager

Research associate