Strong background in bone diseases, virology, neurosciences, nephrology
Holder of a Ph.D in Biochemistry, Cellular and Molecular Biology, I have been focused on the preclinical development of therapeutic molecules, the elucidation of the mechanisms of action of these molecules and the discovery of the mechanisms involved in human pathologies (osteoarthritis, genetic brain and kidney diseases).
In this context, beyond technical skills, I have developed soft skills which allowed me to carry out the missions I have been entrusted :
Management skills :
Supervision of CROs
Coordination of expert networks
Team supervision
Scientific project management
Communication skills :
Reporting
Written and oral presentation of data
Redaction of scientific projects and documents
Scientific skills :
Study design
Development of procedures
Bibliographic and technological survey
Project review
The development of therapeutic molecules is still topical and remains a public health challenge in which I still want to get involved as a preclinical R&D project manager.
Projects reporting to the CSO, partners and collaborators
Presentation and discussion of data at internal and international meetings
Scientific documents redaction
Writing of a scientific project for funds (BpiFrance-Deeptech
Propose and write a preclinical development plan
Scientific skills :
Identify project objectives
From hit to lead (RNA)
Study plans definition and design
Design and development of GLP experimental procedures
Analyses and interpretation of results
Team working and troubleshooting abilities
Literature and technologic survey
Detailed Description
Achievements : Identification of 20 candidate antiviral molecules (Zika, Dengue, Chikungunya) Design, follow-up and completion of 2 in vitro efficacy studies, 2 in vivo efficacy studies Management of an international network of 10 CROs Review of 10 CRO study reports 1 grant obtained (€1.2 M; Bpifrance Deeptech)
Company Description
Meletios Therapeutics’ aim is to fulfill the urgent and large unmet medical need for broad spectrum treatments against current and emerging viral infections.
This French biotech company was created in April 2020 by a team of high level scientists and experienced biotech managers.
One of our first drug candidate has confirmed its broad-spectrum potential in in vitro and in vivo models on the coronavirus family and influenza H1N1, demonstrating a dual antiviral and anti-inflammatory activity. This molecule will now be developed and tested in order to meet regulatory requirements and enter clinical phase II.
Several drug candidates from Meletios portfolio are currently being tested both in vitro and in vivo and will expand our range of antiviral molecules on different RNA viruses.
Meletios Therapeutics’ goal is to become a global leader in the fight against emerging viral infections by developing innovative broad-spectrum therapeutic solutions.
Implementation of the quality system in the company
Communication skills :
Projects reporting to the CSO, partners and collaborators
Writing of a Scientific Technical Advice to the Belgian (FAMHP) and European (EMA) Health authorities
Presentation and discussion of data at internal and international meetings
Scientific documents redaction
Writing of a scientific project for European funds (Eureka-Eurostars)
Scientific skills :
Study plans definition and design
Design and development of GLP experimental procedures
Analyses and interpretation of results
Team working and troubleshooting abilities
Literature and technologic survey
Review of scientific projects involving animals (member of the ethics committee on animal experimentation n°80)
Detailed Description
Achievements: • Management of an international network of 8 CROs, an in-house team of 2 engineers and 3 academic teams • Design, follow-up and completion of 10 preclinical studies, including 3 regulatory studies (hemolytic test, PK/PD, toxicology) • Review of 10 CRO study reports • Writing and/or reviewing of 40 internal study reports • Implementation of 20 internal procedures (SOPs) • Preparation of a scientific and technical advice (STA) to Belgian and European health authorities • Implementation of a corporate quality system and regular internal meetings • Development of an animal model of traumatic osteoarthritis in collaboration with a CRO • Review of 3 projects involving animals (member of the CEEA no. 80) • Writing and publication of 1 article in the Plos One journal • Writing of 4 annual reports, 9 abstracts and 5 posters • 2 oral presentations in plenary sessions at international meetings (OARSI and ICRS) • Preparation and submission of a project for European funding (Eureka-Eurostars: €1.9 M)
Trainings :- ISO 9001 quality systemOctober 2019
Certificate of competence for animal experimentation - design and implementation of proceduresEcole nationale vétérinaire d'AlfortSeptember 2017
Publication :- REG-O3 Chimeric Peptide Combining Growth Hormone and Somatostatin Sequences Improves Joint Function and Prevents Cartilage Degradation in Rat Model of Traumatic Knee Osteoarthritis.Rodrick Montjean, Sonia Escaich, Raffaello Paolini, Claude Carelli, Sébastien Pirson, Thibaut Neutelings, Yves Henrotin, Christelle Vêtu. PLoS One. 2020 Apr14;15(4):e0231240. https://pubmed.ncbi.nlm.nih.gov/32287299
Oral Communications :- REG-O3 Chimeric Peptide combining Growth Hormone and Somatostatin sequences slows down Traumatic Knee Osteoarthritis Progression in Rat.Rodrick Montjean, Sonia Escaich, Raffaello Paolini, Claude Carelli, Yves Henrotin, Christelle Vêtu. ICRS meeting 5th-8th october 2019 (Vancouver, Canada). https://www.emedevents.com/c/medical-conferences-2019/icrs-2019-world-congress-vancouver
New chimeric peptides regulating IGF-1 show significant therapeutic effect on anterior cruciate ligament transection rabbit model of osteoarthritis.Rodrick Montjean, Sonia Escaich, Raffaello Paolini, Claude Carelli, Yves Henrotin, Christelle Vêtu. OARSI meeting 26th-29th april 2018 (Liverpool, UK). https://www.oarsi.org/events/oarsi-2018-world-congress-0
Chimeric Peptide combining both Growth Hormone and Somatostatin sequences (REG-O3) Improves Function and Prevents Cartilage Degradation in Rat Model of Osteoarthritis.Rodrick Montjean, Sonia Escaich, Raffaello Paolini, Claude Carelli, Yves Henrotin, Christelle Vêtu. OARSI meeting 2nd-5th may 2019 (Toronto, Canada). https://www.oarsi.org/event/OARSI-2019-world-congress
New hope for knee osteoarthritis: IGF-1-regulating chimeric peptides showing therapeutic activity on knee osteoarthritis are well tolerated in vivo. Raffaello Paolini, Rodrick Montjean, Claude Carelli, Christelle Vêtu. 26th Young Research Fellows meeting 20th-22nd february 2019 (Paris, France). https://www.dndi.org/2019/media-centre/events/26th-young-research-fellows-meeting/
Le peptide chimérique REG-O3 réduit la douleur et protège le cartilage chez le rat souffrant d’arthrose après méniscectomie partielle et section du ligament croisé.Rodrick Montjean, Sonia Escaich, Claude Carelli, Yves Henrotin, Christelle Vêtu. 31e congrès français de rhumatologie 9th-11th december 2018 (Paris, France). https://sfr.larhumatologie.fr/agenda/31e-congres-francais-rhumatologie
REG-O3, new chimeric peptides regulating IGF-1 pathway: significant therapeutic effect on ACLT rabbit model of osteoarthritis.Raffaello PAOLINI, Rodrick MONTJEAN and Christelle VETU. ICRS meeting 9th-12th april 2018 (Macau, China). https://10times.com/icrs-qa
Company Description
Based at BIOCITECH the technology park of life science of Paris North area. The company is engaged in the research, development and licensing of innovative synthetic molecules for use in human therapies. Its mission is to grant licenses of innovative molecules in a pharmaceutical company after the establishment of a phase II clinical record.
Elucidation of the genetics, molecular and cellular mechanisms of the neurological features in the frame of OCRL mutations (Lowe syndrome vs Dent disease-2)
Management skills :
Technical team supervision (2 technicians, 3 students)
National and International collaboration (France, Germany)
In charge of consumable (inventory management)
In charge of a wild-field microscope
Communication skills :
Project reporting to the supervisor
Presentation and discussion of data internally and externally (6 poster presentations at both national/international meetings)
Data presentation to financial support organizations (3 oral communications)
Scientific documents redaction (4 published scientific articles, 9 abstracts and 6 posters)
Writing of 3 scientific projects for funds (3 grants obtained via Orange Foundation, Jérôme Lejeune Foundation, French Lowe Syndrome Association)
Scientific skills :
Design and development of GLP experimental procedures
Analyses and interpretation of results
Team working and troubleshooting abilities
Literature survey
Training :
Basis of Image J software Cochin Institute December 2012
Publications :
Ptchd1 deficiency induces excitatory synaptic and cognitive dysfunctions in mouse. Ung DC, Iacono G, Méziane H, Blanchard E, Papon MA, Selten M, van Rhijn JR, Montjean R, Rucci J, Martin S, Fleet A, Birling MC, Marouillat S, Roepman R, Selloum M, Lux A, Thépault RA, Hamel P, Mittal K, Vincent JB, Dorseuil O, Stunnenberg HG, Billuart P, Nadif Kasri N, Hérault Y, Laumonnier F. Mol Psychiatry. 2018 May;23(5):1356-1367. https://www.ncbi.nlm.nih.gov/pubmed/28416808
Functional Characterization and Rescue of a Deep Intronic Mutation in OCRL Gene Responsible for Lowe syndrome. Rendu J, Montjean R, Coutton C, Suri SM, Chicanne G, Petiot PA, Brocard J, Grunwald D, Rouxel FP, Payrastre B, Lunardi J, Dorseuil O, Marty I, Fauré Hum Mutat. 2017 Feb;38(2):152-159. https://www.ncbi.nlm.nih.gov/pubmed/27790796
OCRL-mutated fibroblasts from patients with Dent-2 disease exhibit INPP5B-independent phenotypic variability relatively to Lowe syndrome cells. Montjean R, Aoidi R, Desbois P, Rucci J, Trichet M, Salomon R, Rendu J, Fauré J, Lunardi J, Gacon G, Billuart P, Dorseuil O. Hum Mol Genet. 2015 Feb 15;24(4):994-1006. http://www.ncbi.nlm.nih.gov/pubmed/25305077
X-exome sequencing of 405 unresolved families identifies seven novel intellectual disability genes. Hu H, Haas SA, Chelly J, Van Esch H, Raynaud M, de Brouwer AP, Weinert S, Froyen G, Frints SG, Laumonnier F, Zemojtel T, Love MI, Richard H, Emde AK, Bienek M, Jensen C, Hambrock M, Fischer U, Langnick C, Feldkamp M, Wissink-Lindhout W, Lebrun N, Castelnau L, Rucci J, Montjean R, Dorseuil O, Billuart P, Stuhlmann T, Shaw M, Corbett MA, Gardner A, Willis-Owen S, Tan C, Friend KL, Belet S, van Roozendaal KE, Jimenez-Pocquet M, Moizard MP, Ronce N, Sun R, O'Keeffe S, Chenna R, van Bömmel A, Göke J, Hackett A, Field M, Christie L, Boyle J, Haan E, Nelson J, Turner G, Baynam G, Gillessen-Kaesbach G, Müller U, Steinberger D, Budny B, Badura-Stronka M, Latos-Bieleńska A, Ousager LB, Wieacker P, Rodríguez Criado G, Bondeson ML, Annerén G, Dufke A, Cohen M, Van Maldergem L, Vincent-Delorme C, Echenne B, Simon-Bouy B, Kleefstra T, Willemsen M, Fryns JP, Devriendt K, Ullmann R, Vingron M, Wrogemann K, Wienker TF, Tzschach A, van Bokhoven H, Gecz J, Jentsch TJ, Chen W, Ropers HH, Kalscheuer VM Mol Psychiatry. 2016 Jan;21(1):133-48. http://www.ncbi.nlm.nih.gov/pubmed/25644381
Oral communications :
Syndrome de Lowe et maladie de Dent : étude fonctionnelle d’un gène modificateur Rodrick Montjean et Olivier Dorseuil Assemblée Générale de l’Association du Syndrome de Lowe (Paris, France. 19th march 2016).
Syndrome de Lowe et maladie de Dent: Analyses moléculaires et cellulaires comparatives de fibroblastes de patients. Rodrick Montjean et Olivier Dorseuil Assemblée Générale de l’Association du Syndrome de Lowe (Paris, France. 3rd may 2014).
Syndrome de Lowe : Conséquences sur les cellules du système nerveux (Analyse de la morphologie neuronale) Rodrick Montjean et Olivier Dorseuil Assemblée Générale de l’Association du Syndrome de Lowe (Paris, France. 6th april 2013)
Poster communications :
Characterization of Neuronal Morphology Associated with Inactivation of Intellectual Disability and Autism Spectrum Disorders Genes. R. Montjean, F. Paul, J. Rucci, M. Ramos, J. Renaud, G.Pavlovic, MC. Birling, G. Iacono, H. Stunnenberg, M. Selloum, Y. Herault, J. Chelly, O. Dorseuil and P. Billuart. 2nd International GENCODYS Conference Integrative Networks in Intellectual Disabilities (Chania, Crete, Greece. 27th-29th April 2015,). http://www.gencodys.eu/conference2015/conference2015.php
Cellular and molecular mechanisms involved in intellectual deficiency of patients with Lowe syndrome Rodrick Montjean, Rifdat Aoidi, Pierrette Desbois, Justine Galissant, Julien Rucci, Michaël Trichet, Nicolas Lebrun, John Rendu, Julien Fauré, Rémi Salomon, Joël Lunardi, Jamel Chelly, Gérard Gacon, Pierre Billuart and Olivier Dorseuil. EMBO Conference-Autism and related disorders: From bench to bed (La Ciotat, France. 5th-8th September 2014). http://events.embo.org/14-brain/
Compensatory mechanisms between OCRL1-mutated fibroblasts from Lowe syndrome and Dent disease patients. Rodrick Montjean, Rifdat Aoidi, Julien Rucci, Justine Galissant, Michael Trichet, Pierrette Desbois, Joel Lunardi, Rémi Salomon, Nicolas Lebrun, Jamel Chelly, Gérard Gacon, Pierre Billuart and Olivier Dorseuil. Congress of Young Researchers- René Descartes (Paris, France. October 2013) http://www.jcard.fr/index.php?page=congres
Cognitive Disorder Genes And Neuronal Morphology Characterization J Rucci, R Montjean, M Ramos, J Renaud, F Laumonnier, H Stunnenberg, J Chelly, O Dorseuil, And P Billuart 4th European Synapse Meeting (Bordeaux, France. 28th-30th August 2013) http://esm-bordeaux2013.risc.cnrs.fr/
Circadian regulations of hippocampal genes and role of Ophn1, an intellectual disability gene J.Renaud, R. Montjean F.Dumont, S.Jacques, J.Chelly, P. Billuart and O.Dorseuil Gencodys 1st international conference, Integrative networks in intellectual disabilities (Paphos, Chypre. 15-17th april 2013). http://www.gencodys.eu/Conference/
ID genes and synaptopathy J.Rucci, R.Montjean, M.Ramos, J.Renaud, J.Chelly, O.Dorseuil and P. Billuart Gencodys 1st international conference, Integrative networks in intellectual disabilities (Paphos, Chypre. 15-17th april 2013). http://www.gencodys.eu/Conference/
National and International collaboration (France, Denmark)
Communication skills :
Project reporting to the supervisor
Presentation and discussion of data internally and externally (4 poster presentations at international meetings)
Scientific documents redaction (2 published scientific articles, 4 abstracts and 4 posters)
Participation in scientific articles reviewing
Scientific skills :
Design and development of GLP experimental procedures
Analyses and interpretation of results
Team working and troubleshooting abilities
Literature survey
Publications :
Inversin/Nephrocystin-2 is required for fibroblast polarity and directional cell migration. Veland IR, R Montjean, Eley L, Pedersen LB, SF Pedersen, Schwab A, Goodship J, Saunier S, ST Christensen PLoS One. 2013 Apr 8, 8(4). http://www.ncbi.nlm.nih.gov/pubmed/23593172
INF2 mutations in Charcot-Marie-Tooth disease with glomerulopathy. Boyer O, Nevo F, Plaisier E Funalot B Gribouval O, Benoit G, Cong EH, Arrondel C, Head MJ, Montjean R, Richard L, Karras A, Pouteil-Noble C, Balafrej L Bonnardeaux A Canaud G Charasse C Dantal J, Deschenes G, Deteix P, Dubourg O, Petiot P, Pouthier D Leguern E, Guiochon-Mantel A, Broutin I, Gubler MC, Saunier S, Ronco P, Vallat JM, Alonso MA, Antignac C Mollet G. N Engl J Med. 2011 Dec 22; 365 (25):2377-88. http://www.ncbi.nlm.nih.gov/pubmed/22187985
Oral communication :
Nephrocystin-1 and nephrocystin-4 regulate the Wnt pathway and are required for ciliogenesis and epithelial morphogenesis Helori Gaudé, Céline Burcklé, Rodrick Montjean, Flora Silbermann, Emilie Montenont, Marion Delous, Christine Vesque, Cécile Jeanpierre, Alexandre Benmerah, Philippe Bastin, Corinne Antignac, Sylvie Schneider-Maunoury and Sophie Saunier ASN, kidney week 2011 (Philadelphia, USA. 10th-13th november 2011). https://www.asn-online.org/education/kidneyweek/archives/past.aspx
Poster communications :
Nephrocystin-1, nephrocystin-4 and nephrocystin-8 regulate Dishevelled and the Wnt pathway and are required for ciliogenesis and epithelial morphogenesis. Helori Gaudé, Rodrick Montjean, Flora Silbermann, Valentina Grampa, Céline Burcklé, Emilie Montenont, Marion Delous, Christine Vesque, Cécile Jeanpierre, Corinne Antignac, Fabiola Terzi ,Sylvie Schneider-Maunoury, Sophie Saunier Cilia 2012, 1st international scientific conference (London, UK. 17th-18th may 2012). http://www.eventbrite.com/e/cilia-2012-1st-international-scientific-conference-tickets-2201013290
Nephrocystin-1 and nephrocystin-4 : role in cell migration, adhesion and Rho GTPases activation. Helori Gaudé, Rodrick Montjean, Flora Silbermann, Emilie Montenont, Céline Burcklé, Marion Delous, Corinne Antignac and Sophie Saunier. 6èmes journées «Cils, flagelles, centrosomes» (Lyon, France. 15th-16th novembrer 2011).
Loss of NPHP1 and NPHP4 in MDCK cells leads to an over activation of Rho GTPases and actin cytoskeleton reorganization Rodrick Montjean, Flora Silbermann, Helori-Maël Gaudé, Marion Delous, Corinne Antignac and Sophie Saunier 5èmes journées «Cils, flagelles, centrosomes» (Dourdan, France. 20th-21th october 2010).
Elucidate the molecular and cellular mechanisms involved in the renal features of the Lowe syndrome.
Management skills :
Scientific project management (timelines)
National collaboration
Students supervision
In charge of cell culture reagents (testing, inventory management)
Communication skills :
Project reporting to the supervisor
Presentation and discussion of data internally and externally (1 poster presentation during a national meeting)
Scientific skills :
Design and development of GLP experimental procedures
Analyses and interpretation of results
Team working and troubleshooting abilities
Literature survey
Poster communication :
Renal tubular cells of Lowe patients exhibit defective albumin uptake, associated with dysregulation of a Rac GTPase pathway and alteration of Actin cytoskeleton. Rodrick Montjean, Michaël Trichet, Pierrette Desbois, Rémi Salomon, Joël Lunardi, Gérard Gacon and Olivier Dorseuil. 12th annual meeting of the «club Exocytose-Endocytose» (Presqu'île de Giens, France. 4th-6th june 2009)
Elucidate the molecular and cellular mechanisms involved in the renal features of the Lowe syndrome.
Management skills :
Scientific project management (timelines)
National collaboration
Students supervision
In charge of cell culture reagents (testing, inventory management)
Communication skills :
Project reporting to the supervisor
Presentation and discussion of data internally and externally (7 poster presentations at national and international meetings)
Scientific documents redaction (1 published scientific article, 7 abstracts and 7 posters)
Writing of 4 scientific projects for funds (4 grants obtained via Association pour la Recherche sur le Cancer, Fondation pour la Recherche Médicale, Conseil Régional de la Martinique, French Lowe Syndrome Association)
Scientific skills :
Design and development of GLP experimental procedures
Analyses and interpretation of results
Team working and troubleshooting abilities
Literature survey
Trainings :
Scientific images edition with Photoshop software INSERM June 2006
Fire training and handling of fire extinguishers Faculty of Medicine Paris Descartes May 2006
Awareness of the prevention of occupational hazards in research laboratories INSERM November 2005
Publications : The iodide transport NIS Regulates cell motility and invasiveness by interacting with the RhoGEF LARG cancer. Claire Lacoste, Julie Herve Myriam Bou Nader, Moniaux Nicolas, Alexandre Dos Santos, Yannick Valogne, Rodrick Montjean, Dorseuil Olivier, Didier Samuel, Doris Cassio, Carla Portulano, Nancy Carrasco, Christian Bréchot & Jamila Faivre. Cancer Res. 1 November 2012, 72 (21) :5505-15. http://www.ncbi.nlm.nih.gov/pubmed/22962269
Poster communications: Upregulation of the sodium iodide symporter in cholangiocarcinoma is associated with increased cell migration and invasion C. Lacoste, J. Herve, N. Moniaux, F. Faitot, A. Dos Santos, R. Montjean, O. Dorseuil, D. Samuel, D. Cassio, C. Brechot, J. Faivre American Association for the Study of Liver Diseases: Liver Meeting (Boston, USA. 29th oct- 2nd november 2010) http://www.hepmag.com/conference/aasld2010.shtml
Syndrome Oculo-Cérébro-Rénal de Lowe et protéine Ocrl1 : étude dans les cellules du système nerveux et du cristallin Michaël Trichet, Rodrick Montjean, Pierrette Desbois, Gérard Gacon, Olivier Dorseuil. 11éme forum de l'école doctorale Gc2iD (Rueil-Malmaison, France. 20th-21th march 2008).
Rôle physiologique d'OCRL1, la protéine altérée dans le syndrome de Lowe, à la membrane plasmique de fibroblastes cutanés Rodrick Montjean, Adèle Faucherre, Michaël Trichet, Pierrette Desbois, Gérard Gacon et Olivier Dorseuil 10éme forum de l'école doctorale Gc2iD (Rueil-Malmaison, France. 30th-31th march 2007).
Role of Ocrl1, the Lowe protein, in fibroblasts plasma membrane Rodrick Montjean, Adèle Faucherre, Michaël Trichet, Pierrette Desbois, Gérard Gacon, Olivier Dorseuil. Cell migration in development and disease (Paris, France. 20th-21th November 2006).
Etude des mécanismes moléculaires d’action d’Ocrl1 (PIP 5 phosphatase et RhoGAP) à la membrane plasmique des fibroblastes Rodrick Montjean, Adèle Faucherre, Pierrette Desbois, Gérard Gacon, Olivier Dorseuil Colloque des «petites protéines G» (Toulouse, France. May 2005).
Interaction de la protéine OCRL1 avec les GTPases Rho et conséquences fonctionnelles dans les cellules de patients Lowe A. Faucherre, R. Montjean, P.Desbois, V. Satre , J. Lunardi , O. Dorseuil, G. Gacon Colloque «GIS maladies rares» (30th-31th may 2005). http://www.myobase.org/opac/index.php?lvl=notice_display&id=47473