I am a BioAnalyst with more than 15 years of experience in the field of Analytical Chemistry. I have worked with Small Molecules as well as Cyclic Peptides. Enthusiastic and very dedicated, I love nothing more than a challenge when it comes to analysing a high/medium throughput ADMET assay or developing and validating a method for the analysis of PK samples.
Working with small challenging cyclic peptides in two areas: PK: method development, sample preparation and analysis by UPLC-MS/MS of in-vivo samples. ADMET: implementation of medium throughput screening platform for the analysis of Caco-2, Plasma Stability, Microsomal Stability and Protein Binding samples. The platform consists of two Waters Xevo-TQD with UPLC I-Class on the front end, which are run in parallel.
Responsible for the planning, the sample preparation and the analysis by UPLC-MS/MS of in-vivo samples. Responsible analyst in a Lead Optimisation project.
Line manager of 4 analysts. Responsible for the planning of in-vivo analysis, the sample preparation and the analysis by LC-MS/MS. Responsible analyst in a Lead Optimisation project.
Co-ordinator of in-vivo analysis. In charge of 2 analysts. Responsible analyst in a Lead Optimisation project. Initiation to metabolites identification.
“Investigations into the analysis of basic drugs and their metabolites, using Quadrupolar and Time of Flight LC/MS”
Detailed Description
This was a cross-section project (ACRN-MS and DMPK) showing that LC/MS can provide a quick and relatively easy identification and quantitation from potential drugs. For this work I was involved in the sample preparation (microsomal incubation) with the DMPK team, followed by its analysis by LC/MS which included method development and spectra interpretation
“Identification of some mummification balms components used in Ancient Egypt, by GC/MS
Detailed Description
This work took place in a study of antique materials initiated by the French Museums using human or animal mummification balms from different parts of Egypt. The first part of this work was the preparation of the samples: methanolysation and silylation were necessary prior to GC/MS analysis using an ion-trap mass spectrometer. This work resulted in a reference report that gave the main EI mass spectra resulting from human and animal balms, and thus provided information on the wax or plant species type used by the Egyptians during mummification.
